What Actually Happens When You Stop Taking a GLP-1
Trial data on stopping semaglutide shows most of the lost weight comes back within a year. Here is what the STEP 1 extension found.
May 15, 2024

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5 stories for“weight loss maintenance”
Trial data on stopping semaglutide shows most of the lost weight comes back within a year. Here is what the STEP 1 extension found.
May 15, 2024

Work in EMBO Reports finds obesity leaves a chemical mark on CD4 T cells that outlasts weight loss. The authors suggest the immune system may need years of sustained maintenance to reset, and say plainly that no long term human study confirms it.
Sep 1, 2026

TRIUMPH-2 and TRIUMPH-3 read out in July, following TRIUMPH-1 in May. Across the programme the triple agonist has produced weight loss in a range no approved obesity drug has reached, with a filing due in early 2027.
Aug 11, 2026

DiRECT reported 46 per cent remission at one year and 36 per cent at two. Among those who lost more than ten kilograms, three quarters were in remission. At five years, the picture is more sobering and more useful.
Aug 12, 2026

Most adults eat about half the fibre they need. The gap matters more than dieters realise, and closing it is not about bran.
May 22, 2024
