Health
Metformin as an Anti-Aging Drug: The Claims Versus the Trial Data
Biohackers take metformin to slow aging, but the trial designed to actually prove that, TAME, still has not finished enrolling.
May 6, 2024
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60 stories for“slow design”
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Health
Slow Breathing Made People Take More Risks, Not Fewer, in a Berlin Brain-Scan Study
Forty-one volunteers who breathed with a long exhale accepted riskier bets for money in an MRI scanner, and those whose heart rhythm responded most showed the strongest reward activity in the brain. A neat result, a small sample, a lesson about calm.
Sep 8, 2026
Health
Chanting Calms People Down, and the Most Likely Reason Is Extremely Boring
Mantra recitation across several religious traditions converges on a slow, sustained, vocalised exhalation. That is also the single breathing pattern with the best evidence for shifting the autonomic nervous system.
Sep 4, 2026
Health
An AI-Designed Lung Drug Made Six Ageing Clocks Run Backwards in a Small Trial. That Is Not the Same as Reversing Ageing
Rentosertib was built to treat pulmonary fibrosis. In 42 patients, blood proteins read by six independent clocks came out three to four years younger after a month. Independent doctors say a younger score is not a younger person.
Sep 15, 2026
Health
GLP-1 Drugs Are Becoming More Than Weight Loss Medicine
Tirzepatide just earned an approval that has nothing to do with the scale. Here is what SELECT, FLOW and the new sleep apnea data show.
Jan 8, 2025
Health
Yoga Works for Back Pain, Slightly, and Sends About Seventeen People per Hundred Thousand to Hospital
A Cochrane review of twenty-one trials found yoga probably better than no exercise for chronic low back pain, with small improvements. Emergency department data shows injury rates rising, most steeply among people over sixty-five.
Sep 4, 2026
Health
France’s June Heatwave Toll: 5,764 Excess Deaths in 2026
A delayed mortality count reveals the June heatwave’s true scale, showing why the deadliest climate disaster can pass quietly behind ordinary causes of death.
Jul 23, 2026
Health
The Diabetes Drug That Turned Out to Be a Kidney Drug
SGLT2 inhibitors were developed to lower blood sugar by making you urinate it out. The glucose effect turned out to be the least interesting thing about them, and the kidney trials changed how this complication is treated.
Jul 25, 2026
Health
What GLP-1 Drugs Actually Do Inside Your Body
GLP-1 receptor agonists did not start as weight loss drugs. Here is the biology behind Ozempic, Mounjaro and the hormone they mimic.
Jan 25, 2024
Health
What Actually Happens When You Stop Taking a GLP-1
Trial data on stopping semaglutide shows most of the lost weight comes back within a year. Here is what the STEP 1 extension found.
May 15, 2024
Health
Six People With Rheumatoid Arthritis Were Given a Cancer Therapy and Three Have Been Off All Medication Since
A phase 1 trial at the Charite in Berlin used CD19 CAR T cells, a treatment built for blood cancers, on patients who had already failed between five and eight biologic drugs. Disease activity fell in every one of them. Three reached medication free remission.
Aug 30, 2026
Health
Retatrutide: The Triple Agonist Still Proving Itself
Retatrutide just posted phase 3 weight loss data hitting three hormone receptors at once. Here is what is confirmed and what remains unproven.
May 27, 2026
